GENOMIC INTELLIGENCE
From genetic uncertainty to clinical action - instantly.
Continuous genomic intelligence for health systems, laboratories, and care teams
SerenityGx delivers real-time, AI-enabled variant intelligence that continuously tracks genomic findings—detecting clinically meaningful changes and enabling timely, actionable care as evidence evolves.
ABOUT
SerenityGx is an AI-driven genomics company focused on transforming how genetic variants are interpreted, monitored, and translated into clinical action over time.
Founded at the intersection of clinical genomics, translational research, and healthcare operations, SerenityGx addresses a critical gap in modern medicine: the lack of scalable infrastructure to continuously reassess genetic findings as new evidence emerges.
Our platform enables health systems and laboratories to move beyond static reports toward longitudinal genomic stewardship—ensuring that variant interpretations remain current, defensible, and clinically meaningful throughout a patient’s journey.
OUR APPROACH
We combine domain expertise in clinical genomics with advanced AI to build a continuous intelligence layer that:
Monitors evolving scientific and clinical evidence
Supports real-time variant re-evaluation
Enables traceable, standards-aligned decision-making
Activates downstream clinical workflows when change matters
SerenityGx is designed to integrate seamlessly into existing healthcare ecosystems—supporting clinicians, laboratories, and health systems in delivering more precise, timely, and equitable care.
MISSION
To deliver continuous, AI-enabled variant intelligence that empowers health systems and laboratories to keep genomic findings current, actionable, and clinically meaningful.
VISION
A future where no patient is left behind by outdated genetic interpretation—and every clinically relevant variant is continuously monitored, reassessed, and translated into action.
WHAT WE DO
A Continuous Genomic Intelligence Layer
SerenityGx is not a static reporting tool. It is a continuous learning genomic intelligence layer that sits on top of sequencing labs, health systems, and digital health platforms.
HOW IT WORKS
SerenityGx transforms genomic data into continuously updated clinical intelligence by:
Monitoring variants as new scientific and clinical evidence emerges
Supporting real-time re-evaluation of variant classifications
Triggering clinical workflows when reclassification or action is required
Providing transparent, auditable rationale aligned with ACMG/AMP standards
This ensures that genomic insights remain current, defensible, and actionable across the care continuum.
WHY IT MATTERS
Genomic interpretation does not end at the time of testing.
Up to 40% of tests return a Variant of Uncertain Significance (VUS)
Most VUS are never systematically
re-reviewedClinicians and labs lack scalable infrastructure for
long-term variant tracking
SerenityGx closes this gap—ensuring patients benefit from evolving science, not just a snapshot in time.
WHO WE SERVE
Empowering healthcare systems, laboratories, and clinicians to deliver precision care through continuous genomic insight.
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Enable longitudinal genomic stewardship, reduce clinical risk, and ensure patients benefit from updated interpretations.
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Extend the value of testing beyond the initial report with scalable, continuous variant review.
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Automates variant monitoring and delivers only clinically actionable updates—reducing the need for manual tracking.
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Embed continuous genomic intelligence into platforms, programs, and population-scale initiatives.
LEADERSHIP
Team Overview
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Heidi Wagner, BSc, PA, MBA,CHE
CHIEF EXECUTIVE OFFICER / CO-FOUNDER
LinkedIn -
Dr. Neil Fleshner, MD, MPH, FRCSC
CHIEF MEDICAL OFFICER / CO-FOUNDER
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Varun Venkatachalam, MSc, MBA
CHIEF PRODUCT OFFICER / CO-FOUNDER
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Dr. George Charames, MSc, PhD, DABMGG, FACMG
CHIEF SCIENTIFIC OFFICER
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Shoukri Kattan
CHIEF TECHNOLOGY OFFICER
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Julie Mak, CGC, MSc
ADVISOR
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Rachel Millson MS, CGC
ADVISOR
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Laura Redondo, CCGC, MSc
ADVISOR
OUR COMMITMENT
We believe that genomic data should not be static. Every clinician and genetic counsellor deserves access to the most current understanding of genetic information—delivered in a way that is actionable, transparent, and integrated into care. SerenityGx is building the infrastructure to make that possible.